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1

Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

Cortés, Antoni, Gracia, Eduard, Moreno, Estefania, Mallol, Josefa, Lluís, Carme, Canela, Enric I., Casadó, Vicent

Journal:

Medicinal Research Reviews

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

2

Ammonium toxicity in different cell lines

Maribel Mirabet, Angels Navarro, Anna Lopez, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

Biotechnology and Bioengineering

Year:

1997

Language:

english

File:

PDF, 524 KB

english, 1997

3

Ecto-adenosine deaminase: An ecto-enzyme and a costimulatory protein acting on a variety of cell surface receptors

Rafael Franco, Josefa Mallol, Vicent Casadó, Carmen Lluis, Enric I. Canela, Carles Saura, Julià Blanco, Francisco Ciruela

Journal:

Drug Development Research

Year:

1998

Language:

english

File:

PDF, 139 KB

english, 1998

4

Adenosine-glutamate receptor–receptor interactions in the central nervous system

Francisco Ciruela, Marisol Escriche, Mikhail M. Soloviev, Enric I. Canela, Javier Burgeño, Josefa Mallol, Wai-Yee Chan, Carmen Lluis, R.A. Jeffrey McIlhinney, Rafael Franco

Journal:

Drug Development Research

Year:

2001

Language:

english

File:

PDF, 165 KB

english, 2001

5

Adenosine/dopamine receptor-receptor interactions in the central nervous system

Rafael Franco, Sergi Ferré, Maria Torvinen, Silvia Ginés, Joëlle Hillion, Francisco Ciruela, Enric I. Canela, Josefa Mallol, Vicent Casadó, Carmen Lluis, Kjell Fuxe

Journal:

Drug Development Research

Year:

2001

Language:

english

File:

PDF, 471 KB

english, 2001

6

Effect of phospholipases and proteases on the [3H]N6-(R)-phenylisopropyladenosine ([3H]R-PIA) binding to A1 adenosine receptors from pig cerebral cortex

Vicent Casadó, Josefa Mallol, Carmen Lluis, Enric I. Canela, Rafael Franco

Journal:

Journal of Cellular Biochemistry

Year:

1991

Language:

english

File:

PDF, 944 KB

english, 1991

7

Adenosine metabolism in kidney slices under normoxic conditions

Julià Blanco, Josefa Mallol, Carmen Lluis, Enric I. Canela, R. Franco

Journal:

Journal of Cellular Physiology

Year:

1990

Language:

english

File:

PDF, 801 KB

english, 1990

8

Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes

Julià Blanco, Enric I. Canela, Joan Sayós, Josefa Mallol, Carme Lluis, Rafael Franco

Journal:

Journal of Cellular Physiology

Year:

1993

Language:

english

File:

PDF, 765 KB

english, 1993

9

Quantum chemical study of the electronic and conformational characteristics of adenosine and 8-substituted derivatives: Functional implications in the mechanism of reaction of adenosine deaminase

Modesto Orozco, Carmen Lluis, Josefa Mallol, Enric I. Canela, Rafael Franco

Journal:

Journal of Pharmaceutical Sciences

Year:

1990

Language:

english

File:

PDF, 593 KB

english, 1990

10

Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes

Carles Saura, Francisco Ciruela, Vicent Casadó, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 858 KB

english, 1996

11

Modulation of GH4 Cell Cycle via A1 Adenosine Receptors

Angels Navarro, Rafael Zapata, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 974 KB

english, 1997

12

Regulation of L-Type Calcium Channels in GH4 Cells via A1 Adenosine Receptors

Rafael Zapata, Angels Navarro, Enric I. Canela, Rafael Franco, Carmen Lluis, Josefa Mallol

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 805 KB

english, 1997

13

Metabotropic glutamate type 1α receptor localizes in low-density caveolin-rich plasma membrane fractions

Javier Burgueño, Carlos Enrich, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco, Francisco Ciruela

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

14

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

Meritxell Canals, Javier Burgueño, Daniel Marcellino, Núria Cabello, Enric I. Canela, Josefa Mallol, Luigi Agnati, Sergi Ferré, Michel Bouvier, Kjell Fuxe, Francisco Ciruela, Carmen Lluis, Rafael Fran

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 353 KB

english, 2004

15

The distribution of A1adenosine receptor and 5′-nucleotidase in pig brain cortex subcellular fractions

Vicent Casadó, Carmen Lluis, Enrique Canela, Rafael Franco, Josefa Mallol

Journal:

Neurochemical Research

Year:

1992

Language:

english

File:

PDF, 1.56 MB

english, 1992

16

Localization of 5′-nucleotidase in bovine brain myelin fraction and myelin subfractions

Vicent Casadó, Josefa Mallol, Jorge Bozal

Journal:

Neurochemical Research

Year:

1988

Language:

english

File:

PDF, 1.47 MB

english, 1988

17

Isolation and characterization of bovine brain myelin distribution of 5′-nucleotidase

Vicent Casadó, Josefa Mallol, Jorge Bozal

Journal:

Neurochemical Research

Year:

1988

Language:

english

File:

PDF, 1.37 MB

english, 1988

18

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation

José M. Martinez-Navio, Núria Climent, Rodrigo Pacheco, Felipe Garcia, Montserrat Plana, Meritxell Nomdedeu, Harold Oliva, Cristina Rovira, Laia Miralles, José M. Gatell, Teresa Gallart, Josefa Mallol

Journal:

Year:

2009

Language:

english

File:

PDF, 360 KB

english, 2009

19

Purification and Characterization of Bovine Brain 5′-Nucleotidase

Josefa Mallol Montero, Jorge Bozal Fes

Journal:

Journal of Neurochemistry

Year:

1982

Language:

english

File:

PDF, 727 KB

english, 1982

20

Modification of 5′-Nucleotidase Activity by Divalent Cations and Nucleotides

Josefa Mallol, Jorge Bozal

Journal:

Journal of Neurochemistry

Year:

1983

Language:

english

File:

PDF, 613 KB

english, 1983

21

Adenosine Receptors in Myelin Fractions and Subtractions: The Effect of the Agonist (R)-Phenylisopropyladenosine on Myelin Membrane Microviscosity

Vincent Casadó, Josefa Mallol, Carmen Lluis, Rafael Franco, Enric I. Canela

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 756 KB

english, 1991

22

The Adenosine Receptors Present on the Plasma Membrane of Chromaffin Cells Are of the A2b Subtype

Vicent Casadó, Teresa Casillas, Josefa Mallol, Enric I. Canela, Carmen Lluis, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 731 KB

english, 1992

23

Role of Histidine Residues in Agonist and Antagonist Binding Sites of A1 Adenosine Receptor

Gonzalo Allende, Vicent Casadó, Josefa Mallol, Rafael Franco, Carme Lluis, Enric I. Canela

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 925 KB

english, 1993

24

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease

Ester Angulo, Véronique Noé, Vicent Casadó, Josefa Mallol, Teresa Gomez-Isla, Carmen Lluis, Isidre Ferrer, Carlos J. Ciudad, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 337 KB

english, 2004

25

Molecular mechanisms involved in the adenosine A1 and A2A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

Meritxell Canals, Ester Angulo, Vicent Casadó, Enric I. Canela, Josefa Mallol, Francesc Viñals, William Staines, Barbro Tinner, , Luigi Agnati, Kjell Fuxe, Sergi Ferré, Carmen Lluis, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 525 KB

english, 2005

26

Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)-pia binding to the caudate nucleus

Eduard Gracia, Antoni Cortés, J. Javier Meana, Jesus García-Sevilla, Michael S. Herhsfield, Enric I. Canela, Josefa Mallol, Carmen Lluís, Rafael Franco, Vicent Casadó

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 369 KB

english, 2008

27

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

Laia Canela, Víctor Fernández-Dueñas, Catarina Albergaria, Masahiko Watanabe, Carme Lluís, Josefa Mallol, Enric I. Canela, Rafael Franco, Rafael Luján, Francisco Ciruela

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 920 KB

english, 2009

28

Gi protein coupling to adenosine A1–A2A receptor heteromers in human brain caudate nucleus

Vicent Casadó, Sergio Barrondo, Milena Spasic, Luis F. Callado, Josefa Mallol, Enric Canela, Carmen Lluís, Javier Meana, Antoni Cortés, Joan Sallés, Rafael Franco

Journal:

Journal of Neurochemistry

Year:

2010

Language:

english

File:

PDF, 401 KB

english, 2010

29

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

Carla Ferrada, Estefanía Moreno, Vicent Casadó, Gerold Bongers, Antoni Cortés, Josefa Mallol, Enric I Canela, Rob Leurs, Sergi Ferré, Carme Lluís, Rafael Franco

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 484 KB

english, 2009

30

A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation

Ester Angulo, Vicent Casadó, Josefa Mallol, Enric I. Canela, Francesc Viñals, Isidre Ferrer, Carmen Lluis, Rafael Franco

Journal:

Brain Pathology

Year:

2003

Language:

english

File:

PDF, 485 KB

english, 2003

31

Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV

Climent, Núria, Martinez-Navio, José M, Gil, Cristina, Garcia, Felipe, Rovira, Cristina, Hurtado, Carmen, Miralles, Laia, Gatell, José M, Gallart, Teresa, Mallol, Josefa

Journal:

Immunology & Cell Biology

Year:

2009

Language:

english

File:

PDF, 200 KB

english, 2009

32

Detection of heteromerization of more than two proteins by sequential BRET-FRET

Carriba, Paulina, Navarro, Gemma, Ciruela, Francisco, Ferré, Sergi, Casadó, Vicent, Agnati, Luigi, Cortés, Antoni, Mallol, Josefa, Fuxe, Kjell, Canela, Enric I

Journal:

Year:

2008

Language:

english

File:

PDF, 369 KB

english, 2008

33

Calcium mobilization in Jurkat cells via A2b adenosine receptors

Maribel Mirabet, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 367 KB

english, 1997

34

Dipropylcyclopentylxanthine triggers apoptosis in Jurkat T cells by a receptor-independent mechanism

Mirabet, Maribel, Mallol, Josefa, Lluis, Carmen, Franco, Rafael

Journal:

Cell Death & Differentiation

Year:

1997

Language:

english

File:

PDF, 373 KB

english, 1997

35

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins

Francisco Ciruela, Laia Canela, Javier Burgueño, Ana Soriguera, Nuria Cabello, Enric I. Canela, Vicent Casadó, Antonio Cortés, Josefa Mallol, Amina S. Woods, Sergi Ferré, Carmen Lluis, Rafael Franco

Journal:

Journal of Molecular Neuroscience

Year:

2005

Language:

english

File:

PDF, 331 KB

english, 2005

36

Partners for adenosine A1receptors

Rafael Franco, Francisco Ciruela, Vicent Casadó, Antonio Cortes, Enric I. Canela, Josefa Mallol, Luigi F. Agnati, Sergi Ferré, Kjell Fuxe, Carmen Lluis

Journal:

Journal of Molecular Neuroscience

Year:

2005

Language:

english

File:

PDF, 298 KB

english, 2005

37

Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase

Modesto Orozco, Carmen Lluis, Josefa Mallol, Enric I. Canela, Rafael Franco

Journal:

Molecular Informatics

Year:

1989

Language:

english

File:

PDF, 563 KB

english, 1989

38

A1Adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding

Vicent Casadó, Josefa Mallol, Rafael Franco, Carme Lluis, Enric I. Canela

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1994

Language:

english

File:

PDF, 696 KB

english, 1994

39

Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics

Vicent Casadó, Josefa Mallol, Enric I. Canela, Rafael Franco, Carmen Lluis

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1992

Language:

english

File:

PDF, 825 KB

english, 1992

40

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist–antagonist binding modulation

Vicent Casadó, Carla Ferrada, Jordi Bonaventura, Eduard Gracia, Josefa Mallol, Enric I. Canela, Carmen Lluís, Antoni Cortés, Rafael Franco

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 296 KB

english, 2009

41

Novel pharmacological targets based on receptor heteromers

Rafael Franco, Vicent Casadó, Antonio Cortés, Kamil Pérez-Capote, Josefa Mallol, Enric Canela, Sergi Ferré, Carme Lluis

Journal:

Brain Research Reviews

Year:

2008

Language:

english

File:

PDF, 663 KB

english, 2008

42

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: The receptor–dimer cooperativity index

Vincent Casadó, Antoni Cortés, Francisco Ciruela, Josefa Mallol, Sergi Ferré, Carmen Lluis, Enric I. Canela, Rafael Franco

Journal:

Pharmacology & Therapeutics

Year:

2007

Language:

english

File:

PDF, 1.00 MB

english, 2007

43

GPCR homomers and heteromers: A better choice as targets for drug development than GPCR monomers?

Vicent Casadó, Antoni Cortés, Josefa Mallol, Kamil Pérez-Capote, Sergi Ferré, Carmen Lluis, Rafael Franco, Enric I. Canela

Journal:

Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 324 KB

english, 2009

44

Dimer-based model for heptaspanning membrane receptors

Rafael Franco, Vicent Casadó, Josefa Mallol, Sergi Ferré, Kjell Fuxe, Antonio Cortés, Francisco Ciruela, Carmen Lluis, Enric I. Canela

Journal:

Trends in Biochemical Sciences

Year:

2005

Language:

english

File:

PDF, 226 KB

english, 2005

45

Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line

Angels Navarro, Rafael Zapata, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

Year:

1999

Language:

english

File:

PDF, 2.83 MB

english, 1999

46

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

Rafael Franco, Meritxell Canals, Daniel Marcellino, Sergi Ferré, Luigi Agnati, Josefa Mallol, Vicent Casadó, Francisco Ciruela, Kjell Fuxe, Carmen Lluis, Enric I. Canela

Journal:

Trends in Biochemical Sciences

Year:

2003

Language:

english

File:

PDF, 925 KB

english, 2003

47

Solubilization and molecular characterization of the nitrobenzylthioinosine binding sites from pig kidney brush-border membranes

Francisco Ciruela, Julià Blanco, Enric I. Canela, Carmen Lluis, Rafael Franco, Josefa Mallol

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1994

Language:

english

File:

PDF, 958 KB

english, 1994

48

Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors

Francisco Ciruela, Carles Saura, Enric I. Canela, Josefa Mallol, Carmen Lluis, Rafael Franco

Journal:

Year:

1996

Language:

english

File:

PDF, 456 KB

english, 1996

49

The neuronal Ca2+-binding protein 2 (NECAB2) interacts with the adenosine A2A receptor and modulates the cell surface expression and function of the receptor

Laia Canela, Rafael Luján, Carme Lluís, Javier Burgueño, Josefa Mallol, Enric I. Canela, Rafael Franco, Francisco Ciruela

Journal:

Molecular and Cellular Neuroscience

Year:

2007

Language:

english

File:

PDF, 1.72 MB

english, 2007

50

N-ethylmaleimide affects agonist binding to A1adenosine receptors differently in the presence than in the absence of ligand

Gonzalo Allende, Rafael Franco, Josefa Mallol, Carmen Lluis, Enric I Canela

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 387 KB

english, 1991

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